Message boards : Cafe Rosetta : Chat with Rosetta admins/developers
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[VENETO] boboviz Send message Joined: 1 Dec 05 Posts: 1997 Credit: 9,747,451 RAC: 10,562 |
Periodically Foldit admins/devs chat with volunteers to have feedbacks/suggestions/etc (http://fold.it/portal/chats) Why not Rosetta?? |
Abulfetouh Khaled Abulfetouh Send message Joined: 6 Dec 14 Posts: 4 Credit: 28,768 RAC: 0 |
About Fighting AIDS Dear sirs ,madams My idea is about fighting not only HIV but also all viruses which i call "virus traps". as i guess the weakest point in the life cycle of any virus is "Attachment" to target cell ,before that it's secured inside its capsid and after that it's mastering the vital processes in the target cell ,so the only time that is the perfect time to attack it is the "Attachment" time. How could we do that? Simply if we designed a protein/proteins that mimic the target receptor e.g. CD4 molecule for HIV that has higher affinity for the viral navigating molecule which binds more firmly and induces conformational changes that uncoats the virus from it's protective capsid -without being introduced to any cell- then we get naked virus genome and enzymes floating freely unprotected in the blood stream left for the brilliance of the body waiting for the feedback as soon as possible best regards Abulfetouh Khaled Abulfetouh Mohammed Dermatologist |
Abulfetouh Khaled Abulfetouh Send message Joined: 6 Dec 14 Posts: 4 Credit: 28,768 RAC: 0 |
Dear sirs ,madams It's honor to me to participate in this promising work and i'd be glad to share my abstract with you in order to make it easier. I was thinking about what if we arranged the genomic sequences in more mathematical way i.e. as we all know that Adenine base binds to Thiamine base with double hydroxyl bond and more after the Cytosine base binds to Guanine base by triple hydroxyl bond so we have 2 numbers (2 & 3) that represent them and while the order is alternating between A-T / T-A and G-C/G-C so we can use 3 - 3` / 2 and 2`to represent the base in simple way and by using Series Math and Algorithms methods we can calculate it faster and easier to uncover the genomic mystery waiting for the feedback as soon as possible best regards Abulfetouh Khaled Abulfetouh Mohammed Dermatologist |
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