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Profile [VENETO] boboviz

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Message 77704 - Posted: 1 Dec 2014, 15:12:32 UTC

Periodically Foldit admins/devs chat with volunteers to have feedbacks/suggestions/etc (http://fold.it/portal/chats)
Why not Rosetta??
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Abulfetouh Khaled Abulfetouh

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Message 77801 - Posted: 2 Jan 2015, 20:05:00 UTC
Last modified: 2 Jan 2015, 20:06:31 UTC

About Fighting AIDS
Dear sirs ,madams
My idea is about fighting not only HIV but also all viruses which i call "virus traps". as i guess the weakest point in the life cycle of any virus is "Attachment" to target cell ,before that it's secured inside its capsid and after that it's mastering the vital processes in the target cell ,so the only time that is the perfect time to attack it is the "Attachment" time. How could we do that? Simply if we designed a protein/proteins that mimic the target receptor e.g. CD4 molecule for HIV that has higher affinity for the viral navigating molecule which binds more firmly and induces conformational changes that uncoats the virus from it's protective capsid -without being introduced to any cell- then we get naked virus genome and enzymes floating freely unprotected in the blood stream left for the brilliance of the body
waiting for the feedback as soon as possible
best regards
Abulfetouh Khaled Abulfetouh Mohammed
Dermatologist
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Abulfetouh Khaled Abulfetouh

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Message 77802 - Posted: 2 Jan 2015, 20:06:01 UTC
Last modified: 2 Jan 2015, 20:06:42 UTC

Dear sirs ,madams
It's honor to me to participate in this promising work and i'd be glad to share my abstract with you in order to make it easier. I was thinking about what if we arranged the genomic sequences in more mathematical way i.e. as we all know that Adenine base binds to Thiamine base with double hydroxyl bond and more after the Cytosine base binds to Guanine base by triple hydroxyl bond so we have 2 numbers (2 & 3) that represent them and while the order is alternating between A-T / T-A and G-C/G-C so we can use 3 - 3` / 2 and 2`to represent the base in simple way and by using Series Math and Algorithms methods we can calculate it faster and easier to uncover the genomic mystery
waiting for the feedback as soon as possible
best regards
Abulfetouh Khaled Abulfetouh Mohammed
Dermatologist
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