"While most protein-folding researchers look at the sequence of amino acids in a protein, either through X-ray crystallography of folded proteins or through computer simulations, Onuchic and colleagues stepped back to look at the DNA sequences that serve as the blueprints for the proteins.
By exploiting the increasingly large database of genomic sequence information, they’re able to increase the accuracy of predicting the structures of folded proteins.
They start by finding points in the protein-encoding genome sequences that appear to change at the same time, even though they may be separated by great distances along the chain."

A better way to predict how proteins fold

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