question about Rosetta

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thom217

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Message 2788 - Posted: 10 Nov 2005, 9:57:44 UTC

I just have some questions concerning Rosetta.
Is the project going to fold most proteins found in the human proteome. If that is the case then isn't Rosetta doing the same work as WCG. Except that WCG is giving priority to proteins that are directly related to diseasse.

Thanks
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Profile Vester
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Message 2794 - Posted: 10 Nov 2005, 11:59:56 UTC
Last modified: 10 Nov 2005, 12:06:24 UTC

WCG runs an earlier version of Rosetta. We run Rosetta and make Rosetta better.

Reference
The name of the computer program is Rosetta. It computes a "Rosetta score" that tells how properly folded a protein is as the program tries different foldings. To compute this score, the program considers the packing of amino acids within the protein according to many scoring rules. The lower (more toward the negative) the scores are, the better the folding.

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Profile Keith E. Laidig
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Message 2814 - Posted: 10 Nov 2005, 16:47:45 UTC - in response to Message 2788.  
Last modified: 10 Nov 2005, 16:50:00 UTC

I just have some questions concerning Rosetta.
Is the project going to fold most proteins found in the human proteome. If that is the case then isn't Rosetta doing the same work as WCG. Except that WCG is giving priority to proteins that are directly related to diseasse.

Thanks


Vester is correct. You can read more about the differece elsewhere in the forums, such as this thread.

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Message boards : Rosetta@home Science : question about Rosetta



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