Message boards : Rosetta@home Science : decoys
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Charlie Send message Joined: 25 Mar 06 Posts: 53 Credit: 424,472 RAC: 0 |
When i check the Completed WUs i notice it say 1 completed starting structure or somehting like that than another bit of info than Something about completeing so many decoys they range from 5 to 23ish What do these decoys represent? Are the Modles set in to make sure the Wu is running right or is it a Model created from succesful protien bending and attachment? I have to admit its been 28 years sinc ehigh school biology so most all this is way over my head Charlie |
Christoph Jansen Send message Joined: 6 Jun 06 Posts: 248 Credit: 267,153 RAC: 0 |
When i check the Completed WUs i notice it say 1 completed starting structure or somehting like that than another bit of info than Something about completeing so many decoys they range from 5 to 23ish What do these decoys represent? Are the Modles set in to make sure the Wu is running right or is it a Model created from succesful protien bending and attachment? The way I understand it is that the "decoy" means the structure that was farthest down in the local energy landscape, so it is the place where the energy function has a pit or a trap for the calculation. Your PC first creates a starting model. This model lies somewhere in the giant landscape of possible shapes and thus energies the protein can have. From this model he starts random moves until he finds a deeper depression and then refines the structure found until it seems that he reached the (local) minimum in that depression, a decoy. Then he returns to the starting model and starts again randomly, thus reaching another local minimum and so on. You might look here, where the Rosetta method is described in short. |
Feet1st Send message Joined: 30 Dec 05 Posts: 1755 Credit: 4,690,520 RAC: 0 |
I believe you will find the number of decoys reported is almost always the same as the number of models you've completed, as shown in the graphic at the end of the work unit. Add this signature to your EMail: Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might! https://boinc.bakerlab.org/rosetta/ |
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