The world’s most advanced atomistic foundation model, unifying structure prediction and all-atom de novo generation for the first time - to decode and design the structure of life. Neo-1 is trained to generate molecules and their structures in full-atom resolution from various starting prompts: sequence, structure, properties or masked versions. This makes Neo-1 the most controllable and general atomistic foundation model, replacing a large series of specialist models. It also unlocks end-to-end rational glue design from sequence alone. Neo-1 integrates directly with experimental data, enabling rapid and iterative optimization in drug discovery projects. Applications already include designing molecular glues, PROTACs, and antibodies, significantly accelerating the path from computational design to experimental validation.