Message boards : News : Coronavirus update from David Baker. Thank you all for your contributions!
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S@NL - eFMer - efmer.com Send message Joined: 26 Aug 20 Posts: 3 Credit: 115,812 RAC: 0 |
I think pressing - to collapse is all you need, to stop this to happen |
Greg_BE Send message Joined: 30 May 06 Posts: 5691 Credit: 5,859,226 RAC: 0 |
I am getting spammed continuously by You Tube with this video. I never knew it existed in the first place until it popped up. I found a thread that says if you go into your BOINC data directory and find the notices folder and delete everything. So I did that and only threads came back. All notices are gone. Hopefully this eliminates the spamming I was getting. Here is a short video of David Baker describing some exciting results from de novo designs targeting SARS-Cov-2. |
Falconet Send message Joined: 9 Mar 09 Posts: 353 Credit: 1,227,479 RAC: 917 |
If you use BOINCTasks, see the comments above yours, namely this one - https://boinc.bakerlab.org/rosetta/forum_thread.php?id=14226&postid=99169 If not, maybe disabling the "Check For Notices every X Hours" option works? Open BOINC, Options, Other Options. And I suppose if Rosetta removed the embedded video from this post and resent the notice, the issue would go away. |
Breno Send message Joined: 8 Apr 20 Posts: 30 Credit: 12,961,058 RAC: 6,560 |
The joy of getting a reply from David Baker is great. David and crew, a piece of advise: As the pandemic gets in ''decisive'' stages, I suggest you do a little more marketing for the project. I think you should do something like: "Come on guys, where are almost there". Even if you are not quite there for anything. The reason I say this is because, most people that give computation away are looking for ways to help to develop a vacine or anti-virals, but these people don't really count on the complexity of the entire project. I could argue that it would be wise to surf the rest of this pandemic-collaboration-tsunami for the benefit of the project, because after it, probably, many people will just move on to something else. Anyways, I will keep helping in any way i can, but with smaller computational power. Best wished to D.B. and his team. |
Jim1348 Send message Joined: 19 Jan 06 Posts: 881 Credit: 52,257,545 RAC: 0 |
Insofar as I can tell, Rosetta is done with COVID-19. They have their fix in the bag, and are just testing it. Actually, they have several fixes including the anti-viral, vaccine, and diagnostics. In fact, maybe more than one of each. They have moved on. If there is a new virus, I am sure they will come back in a hurry. |
Falconet Send message Joined: 9 Mar 09 Posts: 353 Credit: 1,227,479 RAC: 917 |
Sure but a very large portion of the COVID-19 pandemic computing power gain is gone already. |
Chooka Send message Joined: 25 Jan 17 Posts: 8 Credit: 11,108,520 RAC: 20,326 |
Thanks for the tips on fixing this. I came back from a holiday and it was open 107 times on my browser!! That was the most annoying thing I've come across in my years with BOINC. |
gemini8 Send message Joined: 25 Feb 12 Posts: 5 Credit: 3,070,850 RAC: 4,047 |
This post should be sent as a notice to all BOINC clients. Somebody listened. Although I was rather surprised (but not annoyed) that it opened the video for me without me touching it! I am annoyed like hell! Screw this! - - - - - - - - - - - - - - - Greetings, Jens |
Jim1348 Send message Joined: 19 Jan 06 Posts: 881 Credit: 52,257,545 RAC: 0 |
I am not sure that this is relevant, but I always set the BOINC "Notice reminder interval" to "Never" when setting up a machine. I don't have any problems with it. (If I did, I would get rid of BOINC.) |
Admin Project administrator Send message Joined: 1 Jul 05 Posts: 4805 Credit: 0 RAC: 0 |
Oh, boy. Just finished catching up with this thread. Sounds like an awful issue. So sorry. It was the iframe embedded video tag that causes the BOINC client to behave this way. It should be fixed now. |
Falconet Send message Joined: 9 Mar 09 Posts: 353 Credit: 1,227,479 RAC: 917 |
Oh, boy. Just finished catching up with this thread. Sounds like an awful issue. So sorry. It was the iframe embedded video tag that causes the BOINC client to behave this way. It should be fixed now. Got a new notice without the video and all that blank space. Clicking on refresh no longer opens a tab on Windows. |
Admin Project administrator Send message Joined: 1 Jul 05 Posts: 4805 Credit: 0 RAC: 0 |
Great. This is one of those situations where you think you're doing a good thing responding to user feedback and then it explodes into something horrible accidentally. David Anderson and Charlie Fenton from the BOINC team alerted me about this issue with the client and the iframe tag, and I fixed it as soon as I realized what was happening. Sorry again to everyone who was affected. |
Falconet Send message Joined: 9 Mar 09 Posts: 353 Credit: 1,227,479 RAC: 917 |
I'm sure it's fine. It's fixed and that is what matters. We always want more feedback and updates :) |
robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,402 |
shows up in edge as new tab. I had about 30 of those tab page coronavirus reports as the computer runs 24/7 and edge was left up overnight. If the browser runs out of room to display tab reports, why shouldn't it start hiding or even deleting the oldest ones? Whether the number shown stops at 30 would then depend on which browser you are using. |
robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,402 |
Actually, aren't the Boinc apps quite restricted to only writing data within their project folder? And if they're not run with admin rights (are they?) they certainly can't mess around with the system files. The BOINC scheduler is usually run with admin rights, at least under Windows; otherwise, it cannot start any tasks that use the GPU. I haven't seen whether any other BOINC programs, such as the apps, need this. |
robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,402 |
Insofar as I can tell, Rosetta is done with COVID-19. They have their fix in the bag, and are just testing it. They NEED more than one fix of each type, in case the virus mutates in a way that disables one of the fixes. Otherwise, the mutated virus would start spreading about as much as the original. There already three known varieties with differences on the outside of the virus, so any new fix needs to be tested against all three of these varieties. There are many other mutations affecting only the inside of the virus; these appear to be significant only if you are trying to trace where the infection came from. The three major varieties are: The most common variety in China. It spread to the US before travel between China and the US was almost completely shut down. A mutation that occurred in Europe, then spread to the US. Travel between Europe on the US was not shut down in time to have much effect on spreading in the US. The spikes and more tightly bound to the body of the virus, and is therefore more infectious. A variety that started in China, spread to Indonesia, and is now the most common variety in Indonesia. It spreads to more people, but is less likely to be fatal. |
Jim1348 Send message Joined: 19 Jan 06 Posts: 881 Credit: 52,257,545 RAC: 0 |
I haven't heard that the vaccines and anti-virals are not effective against all known types. It is said that the virus resists mutation, and these variations appear to be fairly minor. The Rosetta technique is to "cap" the spike with a protein. If that doesn't work for all, I am sure that the will be back here to work on it further. But they don't tell us about it in real-time, so we don't really know until they make a big announcement of some sort. |
Falconet Send message Joined: 9 Mar 09 Posts: 353 Credit: 1,227,479 RAC: 917 |
I think they mentioned on the Science Paper that because they have those 10 different antiviral candidates, the chances of there being resistance and thus rendering the treatment useless are greatly diminished. At least, that was my understanding from this: "The minibinders designed in this work have potential advantages over antibodies as potential therapeutics. Together, they span a range of binding modes, and in combination viral mutational escape would be quite unlikely (figs. S1 and S14 and table S1)." And then there are the Rosetta@home engineered candidates, of which we don't really know anything about but those could be tested and further developed as well, I suppose. |
Breno Send message Joined: 8 Apr 20 Posts: 30 Credit: 12,961,058 RAC: 6,560 |
I'm sorry that I partially caused this from pushing the PR subject over and over on the posts. However, the number of responses alone in this thread point to a positive aspect, since people are participating, which is the whole point of this Forum. Thanks again for the update, and please keep'em coming whenever possible! |
Dingo Send message Joined: 17 Sep 05 Posts: 14 Credit: 4,656,438 RAC: 0 |
I'm sorry that I partially caused this from pushing the PR subject over and over on the posts. Only positive out of this is that Rosetta@ home is losing participants and does not seem to care. Bye |
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